GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9876781 | 1 | rs2290822 | chr3:48473204 | TREX1 | chr3:48501186-48509043:+ | -0.29 | -4.26 | 4.8E-5 | Longevity |
| THYM | cis | rs60843830 | 1 | rs2290911 | chr2:224919 | SH3YL1 | chr2:218138-264810:- | -0.31 | -4.56 | 1.52E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs877636 | 1 | rs2292239 | chr12:56482180 | RPS26 | chr12:56435686-56438005:+ | 0.86 | 9 | 2.29E-14 | Cognitive function |
| THYM | cis | rs2292342 | 1 | rs2292342 | chr19:49118371 | SEC1 | chr19:49141296-49185501:+ | -0.84 | -4.15 | 7.35E-5 | Elevated serum carcinoembryonic antigen levels |
| THYM | cis | rs2294008 | 1 | rs2294008 | chr8:143761931 | PSCA | chr8:143761875-143764142:+ | 0.44 | 4.31 | 3.94E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs2294008 | 1 | rs2294010 | chr8:143762430 | PSCA | chr8:143761875-143764142:+ | 0.43 | 4.29 | 4.22E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| THYM | cis | rs7849270 | 1 | rs2297112 | chr9:131900180 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs2303759 | 1 | rs2303759 | chr19:49869051 | DKKL1 | chr19:49867042-49878371:+ | -0.34 | -4.32 | 3.87E-5 | Multiple sclerosis |
| THYM | cis | rs4663866 | 1 | rs2304668 | chr2:239168448 | LOC151174 | chr2:239133754-239140318:- | 1.03 | 4.7 | 8.82E-6 | Irritable bowel syndrome |
| THYM | cis | rs1875620 | 1 | rs2316803 | chr9:91551990 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.81 | 5.58E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1875620 | 1 | rs2316804 | chr9:91551898 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.68 | 9.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1577917 | 1 | rs2324843 | chr6:86617501 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -7.24 | 1.15E-10 | Response to antipsychotic treatment |
| THYM | cis | rs454422 | 1 | rs2326680 | chr20:5942955 | MCM8 | chr20:5931298-5975829:+ | -0.22 | -4.5 | 1.96E-5 | HIV-1 viral setpoint |
| THYM | cis | rs1451375 | 1 | rs2329340 | chr7:50620229 | FIGNL1 | chr7:50511834-50518088:- | -0.3 | -4.59 | 1.33E-5 | Malaria |
| THYM | cis | rs1451375 | 1 | rs2329341 | chr7:50620275 | FIGNL1 | chr7:50511834-50518088:- | -0.3 | -4.59 | 1.33E-5 | Malaria |